One of the things to surprise me in regards to Savage Worlds is that there's not a more mainstream sci-fi published setting out there. There's Slipstream, but that's a bit too 1930's pulp for my liking to be a good "middle ground" setting.
There are also sci-fi toolkit books for Savage Worlds. Of course toolkit =/= setting. I guess more than anything, I'm just surprised that given the proficiency of SavWo products out there that so many of them fall into more eclectic or esoteric tastes (not that it's a bad thing; I'm glad there's folks trying something new).
I had actually toyed around with my own Savage Worlds sci-fi setting, which I had named Privateer. Basically, it leaned towards imperial sci-fi, with some space opera thrown in for good measure. It would take place in the Europa Cluster, an isolated, primarily human-dominated portion of the galaxy. The powers and factions would be tributes to the political entities existing around the time of the Napoleonic Wars/War of 1812 (not unlike certain aspects of the Honor Harrington series). Characters are likely privateers, given letters of marque by the various scheming powers to raid, destroy, and harry their enemies. There should be a lot of chances for duplicity, battle, intrigue, and all the other good stuff we expect. But I'm not sure that it'll ever get past the embryonic stage, which is a shame, because I think it's a fun idea, one that takes my love of imperial sci-fi, space opera, Traveller, and history and mashes it all up.
I suppose until someone publishes another SavWo, sci-fi setting, at least there are a ton of conversions out there.