-4e holds steady. One of the local stores was having some trouble with its Wednesday night Encounters planning, but I know of a couple groups running 4e campaigns. It's very much a hot or cold game, I think, but fortunately not as polarizing as it once was.
-Pathfinder remains the game of choice among my more immediate contacts; I'm in a Pathfinder game currently, but I know of several others. I'd say in terms of actual play, it's running roughly even with D&D 4e.
-I don't get the feel that a lot of groups are "locked in" to a system. I think that folks are willing to try lots of different games; there isn't as much of the "we play 3.5 and that's all we ever play" deal anymore. Why, I don't know, but that's just how it seems to me.
-Dresden Files still excites a lot of comment and interest, but aside from the brief flare-up from the unusual format of Warhammer Fantasy 3e, that game seems flatter than flat right now.
-I've been invited to two "OSR"-type games, one with Labyrinth Lord and one OSRIC, but I have been unable to make either. Still, it's nice to be asked.
-Aside from what I and several others introduce, small-press games and products are still, well, small-press. ICONS and Eclipse Phase have made an appearance, as have Swords & Wizardry and some issues of Fight On!, but it's spotty.
So how are things right now in your neck of the woods?